Inclusion and exclusion criteria

Inclusion criteria :

(1) Randomized controlled trials or single-arm trials;

(2) Patients diagnosed with relapsed/refractory DLBCL;

(3) At least one of the efficacy indicators of OS, PFS or ORR was reported;

(4) The treatment are chemotherapy, targeted therapy, and immunotherapy alone or in combination.


Exclusion criteria :

(1) Sample size was less than 10;

(2) Patients with other subtypes, DLBCL transformed from other subtypes, or patients with high-risk disease with undiagnosed relapsed/refractory DLBCL.


Details of
search and inclusion

Literature search :

Databases : PubMed , Embase and Cochrane Library

Search deadline : Jan 25, 2021.

Language was limited to English.

The terms used : “relapsed”, “refractory” and “diffuse large B-cell lymphoma” .



Literature inclusion and exclusion:

A total of 854 literatures were identified

624 literatures were screened

106 literatures were assessed for eligibility

58 studies were included in the analysis.



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Detailed search strategies     download

PRISMA flow diagram            download