Inclusion and exclusion criteria

Inclusion criteria :

(1) Patients had a stage II/III colorectal cancer;

(2) Patients had undergone surgical resection;

(3) Patients received the NCCN guideline recommended regimen adjuvant chemotherapy;

(4) Patients had not received any other treatment prior to enrollment;


Exclusion criteria :

(1) Patients had a combination of cancers other than colorectal cancer;

(2) Patients received non-adjuvant chemotherapy regimens.

(3) No survival data was reported.


Details of
search and inclusion

Literature search :

Databases : PubMed, Embase

Search deadline : Dec 29, 2021.

Language was limited to English.

The terms used : “Colorectal cancer”, “Cancer of colon”, “Cancer of rectum”



Literature inclusion and exclusion:

A total of 5564 literatures were identified

4335 literatures were screened

744 literatures were assessed for eligibility

34 studies were included in the analysis.



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Detailed search strategies     download

PRISMA flow diagram            download